Survival A Medical Memoir From Drug Discovery To Clinical Cancer Trials eBook Lorne J Brandes MD
Download As PDF : Survival A Medical Memoir From Drug Discovery To Clinical Cancer Trials eBook Lorne J Brandes MD 
This is the amazing true story of medical research, far outside the box, that led to the discovery of a novel antihistamine (DPPE) that helped chemotherapy drugs cure laboratory mice of cancer while protecting the bone marrow. The book chronicles an inventor's passion to move DPPE from the laboratory to the clinic; the unprecedented facilitation of its development and approval for human use by university and government bureaucrats; the decision of a U.S. pharmaceutical giant that stopped DPPE in its tracks after it was declared inactive at an early time-point in a major breast cancer trial, only to show a marked survival advantage in a follow-up analysis 18 months later; and its dramatic rescue by a small Canadian biotech company that, with a combination of luck, venture capital and the FDA’s blessing, took it back into a final trial needed for its approval. Intertwined with the human drama are the politics and science behind the story, including an unanticipated research finding with implications that shook the public, drug companies and regulatory agencies.
Survival A Medical Memoir From Drug Discovery To Clinical Cancer Trials eBook Lorne J Brandes MD
Survival is a double or even quadruple-entendre in the title of this excellent memoir by someone who really has "been there.". Dr. Brandes survived the rigors and whims of cancer laboratory research, although he has little good to say about many of those who should have more quickly or easily funded his efforts. He and his colleagues then survived the regulatory process to bring his biggest discovery, a drug called DPPE, into clinical research in a way that he acknowledges could not be done now in the 21st century. It seemed that the drug would enhance survival in patients who have breast cancer but, unfortunately (spoiler alert) this early finding could not be confirmed. The author also survived three or four negotiations with "big pharma" and on-again, off-again licensing deals. His opinions on the people he met during those years vary from admiration to disappointment and beyond and he sees no reason now to sugar-coat the truth as he sees it pertaining to the latter group .The book is quite long and detail-intense although it does feel like the good story it is--it would be a great story if the ending had turned out differently but this is not the only book at which that criticism could be leveled! Since it is non-fiction, this aspect is clearly not the author's fault and I'm sure he would have preferred the "alternative ending" for himself and his patients. The photographs are a welcome addition to the many personality and incident descriptions but I found the footnotes a little intrusive although perhaps necessary for a non-scientific reader, which I am not.
Despite the many challenges and obstacles he overcame, not least of these being the Winnipeg winters, and the unkindest cut of all in the end of the story, Dr. Brandes' intelligence, optimism, good humor and doggedness come through as obviously as his respect for many colleagues he was pleased to collaborate with along the way. He is the ultimate survivor of the title and I tip my hat to him and his book.
Product details
|
Tags : Buy Survival: A Medical Memoir: From Drug Discovery To Clinical Cancer Trials: Read 13 Books Reviews - Amazon.com,ebook,Lorne J. Brandes MD,Survival: A Medical Memoir: From Drug Discovery To Clinical Cancer Trials,FriesenPress,MEDICAL Oncology,MEDICAL Research
People also read other books :
- Frailty Betsy Reavley author 9780995621206 Books
- Quest for The Truth The Seldith Chronicles Volume 3 William R Vaughn 9781492319870 Books
- The Moon and Sixpence W Somerset Maugham 9781517397296 Books
- The Beast Without edition by Christian Baines Literature Fiction eBooks
- Little Nurse Amigurumi Crochet Pattern eBook Sayjai Thawornsupacharoen
Survival A Medical Memoir From Drug Discovery To Clinical Cancer Trials eBook Lorne J Brandes MD Reviews
An absolute tour de force! This book relates the highly personalized 20 year search of an internationally-renowned cancer researcher to get a drug to market. Although the drug fails at the very last stage (clinical trials), the description of the journey succeeds in so many positive ways! The process is described in tremendous detail, with an emphasis on the important human interactions amongst the doctors, government regulators and the drug companies in their collective search for the miracle drug to control breast cancer. Highly readable. Worth the time.
This book is a page turner and difficult to put own. It is a personal and very readable account of the elation and disappointments encountered by the inventor on travelling the difficult road to bring his drug to market. The author is an outstanding story teller, who bares everything of his let-downs and many personal losses, the people he encounters (from premiers to academic superstars) and the impact on his family and those close to him. Not many people could accomplish what Dr. Brandes achieved through grit and determination. If you want an insight into the scientists and the industrialists that bring your drugs to market, I highly recommend this memoir. You will enjoy reading it to the very last page.
I have known the author and the outlines of the story for some years and have lived in this world of drug development myself ( full disclaimer) , but this exceptionally well written and detailed account of the drug discovery process exceeded my wildest expectations In an era when big data seems dominate the scientific headlines ,Dr Brandes book reminds us of the power of ideas. The book details the long odyssey of hypothesis based research, and the myriad obstacles that must be overcome to bring the idea to fruition.. It does so in an intimate way that involves the reader as a passenger negotiating the medical, legal, commercial and other twists and turns with him. It is the story of Moby Dick in medicine and you are in the boat. You will enjoy it,be touched by it and learn from it.
This is an in-depth look at how science--and scientists--really work. Dr. Brandes, in this intensely personal memoir, takes the reader along on the bumpy road from idea through lab research, through rodent trials and on to the long and patient work of human clinical trials. He shows the highly collaborative work of science. He makes it clear that a scientist with an unquenchable thirst for answers must be a marketer, a networker and a personable schmoozer to keep the money coming in that allows the work to continue. Ultimately, he shows that even when the idea doesn't yield the hoped-for results, the process and the results have value for future scientists to explore. This is a good read for future researchers as well as the general reader who wants to know how things work.
Very interesting. A real science suspense story difficult to put down once you have started.
Lorne Brandes offers a highly personal view from the bench on what it takes to discover a drug and usher it through clinical trials. The journey isn't for the faint of heart.
Execellent description of challenged faced by academic scientists trying to bring new treatments to patients and having to rely on Pharma companies to do the right thing.
Survival is a double or even quadruple-entendre in the title of this excellent memoir by someone who really has "been there.". Dr. Brandes survived the rigors and whims of cancer laboratory research, although he has little good to say about many of those who should have more quickly or easily funded his efforts. He and his colleagues then survived the regulatory process to bring his biggest discovery, a drug called DPPE, into clinical research in a way that he acknowledges could not be done now in the 21st century. It seemed that the drug would enhance survival in patients who have breast cancer but, unfortunately (spoiler alert) this early finding could not be confirmed. The author also survived three or four negotiations with "big pharma" and on-again, off-again licensing deals. His opinions on the people he met during those years vary from admiration to disappointment and beyond and he sees no reason now to sugar-coat the truth as he sees it pertaining to the latter group .
The book is quite long and detail-intense although it does feel like the good story it is--it would be a great story if the ending had turned out differently but this is not the only book at which that criticism could be leveled! Since it is non-fiction, this aspect is clearly not the author's fault and I'm sure he would have preferred the "alternative ending" for himself and his patients. The photographs are a welcome addition to the many personality and incident descriptions but I found the footnotes a little intrusive although perhaps necessary for a non-scientific reader, which I am not.
Despite the many challenges and obstacles he overcame, not least of these being the Winnipeg winters, and the unkindest cut of all in the end of the story, Dr. Brandes' intelligence, optimism, good humor and doggedness come through as obviously as his respect for many colleagues he was pleased to collaborate with along the way. He is the ultimate survivor of the title and I tip my hat to him and his book.
0 Response to "≡ Read Survival A Medical Memoir From Drug Discovery To Clinical Cancer Trials eBook Lorne J Brandes MD"
Post a Comment